U.S. Open 2018: Djokovic, Cilic, Keys, Osaka onto semifinals

Novak Djokovic Marin Cilic Kei Nishikori Madison Keys are quarterfinal headliners

Japan's Nishikori, who missed last year's US Open after a season-ending wrist injury, joined compatriot Naomi Osaka in reaching the semis - the first time that a Japanese man and woman have reached the last four in the same Grand Slam.

The 20-year-old Osaka then secured a final break to close out the match.

"It's great to see", said Nishikori.

Tsurenko saw her only glimmer of hope when she held a triple break chance at 4-1 in the second set, but Osaka fought back and won the second deuce to hold serve.

"Yeah, always excited to play Novak because it's great challenge for me", said Nishikori about the possibility of facing Djokovic, should the sixth-seeded Serb beat Millman in the quarter-finals. "Especially after coming from injury, I think I'm enjoying this challenge".

The seventh-seeded Cilic won the 2014 final in straight sets for his only career major title.

Cilic did level at 4-4 but his erratic play continued as Nishikori stole the set with the help of two double faults in the tiebreak.

After reaching the final in Monte Carlo, the French Open fourth round and the Wimbledon quarter-finals, Nishikori believes an elusive first grand slam is within reach.

Though Cilic leveled at two sets apiece after the match entered its fourth hour, Nishikori hung on to grab the decisive break, smacking a forehand return victor to seal the match.

Cilic has made two grand slam finals since but Nishikori has never been back and will now take on either twice U.S. Open champion Novak Djokovic or unseeded Australian John Millman for a spot in Sunday's final.

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"It means a lot", Osaka said of her historic win.

"Unfortunately during this tournament I had many issues with my health, and today was not my day obviously". I said, 'Man, go ahead'.

Osaka had consecutive 50-minute matches earlier in the tournament, including a 6-0, 6-0 thrashing of Aliaksandra Sasnovich in the third round.

Cilic dominated the first set on Wednesday, connecting superbly with powerful groundstrokes, and soon moved into a 4-2 lead in the second.

Tsurenko labored in the heat during her fourth-round victory over Marketa Vondrousova, having her temperature and blood checked during a medical timeout in the first set and almost quitting when she trailed early in the second.

It was another hot afternoon Wednesday, with temperatures in the high-80s (30s Celsius) but feeling some 10 degrees hotter with the humidity.

"But Millman is the kind of a player that makes you miss the balls, makes you win the point, earn the point".

"I hate matches like this", Tsurenko said.

On another day of punishing heat and humidity in NY, the world No. 19 Nishikori overcame an early deficit to pull out a five-set win against Cilic, who bested him in the 2014 U.S. Open final. "My entire body was shaking, so I'm really glad I was able to play well today".

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