James Allison, Tasuku Honjo win Nobel Prize in Medicine

The Nobel Prize laureates in medicine or physiology are shown on a screen at the Karolinska Institute in Stockholm Sweden

The Nobel Prize in physiology or medicine was awarded Monday to cancer researchers James Allison, 70, and Tasuku Honjo, 76, whose studies led to the development of drugs that unleash the human immune system against the deadly disease.

Their research led to the discovery that by releasing these "brakes" a person's immune system would be strong enough to attack cancer cells.

Checkpoint inhibitors now available to patients can be used to treat lung, kidney, bladder, head and neck cancers as well as aggressive skin cancer and Hodgkin lymphoma, reports Denise Grady for The New York Times.

In 1992, Japanese scientist, Tasuku Honjo from Kyoto University, separately discovered another protein on immune cells called PD-1 and revealed that it also operates as a brake, but with a different mechanism of action to CTLA-4.

Although the concept of using the immune system against cancer arose in the 19th century, initial treatments based on the approach were only modestly effective.

One of the first patients I was privileged to care for in clinic had completed four rounds of treatment with an experimental drug - three months of infusions of a checkpoint inhibitor (one of which is now on the PBS). "For some patients, we see their tumours shrink or completely disappear and are effectively cured". The discovery was applied for the development of cancer drugs that inhibits the activity of the PD-1 so immune cells can continue to attack cancer cells.

In 2017, United States geneticists Jeffrey Hall, Michael Rosbash and Michael Young were awarded the medicine prize for their research on the role of genes in setting the "circadian clock" which regulates sleep and eating patterns, hormones and body temperature.

Jose Mourinho: Some Manchester United players 'lack technical quality'
Kevin Gameiro who scored last Sunday is expected to lead the line for Valencia alongside Chelsea-loanee Michy Batshuayi . Manchester United were held to a 0-0 draw by Valencia in Tuesday's Champions League clash at Old Trafford.

Google's Project Stream makes 'Assassin's Creed' playable in Chrome
Game streaming is taking off, as services like PlayStation Now and NVIDIA's GeForce Now attract more mainstream attention. The company today announced Project Stream , its take on making game streaming with only your browser a reality.

Facebook’s Big Data Breach Could Cost It Over $1 Billion
Anyway, Facebook has since now patched the vulnerabilities and revoked the affected access tokens that were stolen by hackers. Julian Knight, a committee member, said: "It would be helpful to hear from Mr Zuckerberg, but I won't be holding my breath".

"I'm honored and humbled to receive this prestigious recognition", Allison said in a statement released by M.D. Anderson.

Tasuku Honjo and James P. Allison shown in a composite photo. "After many years of resistance, I think the cancer field has begun to accept immunotherapy now as the fourth pillar-along with radiation, surgery and chemotherapy-of cancer therapy".

"It's a great, emotional privilege to meet cancer patients who've been successfully treated with immune checkpoint blockade", he added. In some cases, some cancer cells also contain these proteins which allow the cells invade the body without much struggle.

The combined work of these two scientists has led to new ways to beat cancer.

Allison and Honjo have previously shared the 2014 Tang Prize, touted as Asia's version of the Nobels, for their research.

News that Honjo became the 26th Japanese Nobel Prize victor was met with a shower of praise from cancer patient groups and the Japanese government on Monday.

Instead, it is "going to be part of therapy that potentially all cancer patients will receive in five years", he told a press conference in NY.

Related news:

Hot News

isis-killer-beheading-video-story-top Packages that may contain ricin found on Pentagon grounds
Oct 03, 2018 - 01:58
The mail distribution center where the mail arrived and was flagged isn't in the Pentagon but nearby, the officials said. CNN reported that the letters were addressed to Secretary of Defense James Mattis and Chief of Naval Operations Adm.

isis-killer-beheading-video-story-top FBI interviews Brett Kavanaugh's friend Mark Judge as part of investigation
Oct 03, 2018 - 01:33
Mr Kavanaugh struck an angry and defiant tone during the hearing, denying allegations made by three women against him. Ludington said he was a varsity basketball and that Kavanaugh enjoyed socializing with athletes.

isis-killer-beheading-video-story-top Kavanaugh friend Dudley arrested in 1985 bar incident
Oct 03, 2018 - 01:30
The man noticed Ludington, Kavanaugh and the others looking at him and - according to Ludington - aggressively asked them to stop. Dudley stressed that while he and Kavanaugh drank together in college, he never saw Kavanaugh black out.

isis-killer-beheading-video-story-top Napoli v Liverpool: Jurgen Klopp dismisses Carlo Ancelotti praise as 'tactics'
Oct 03, 2018 - 01:29
He's too big, too strong, too quick, too good on the ball, he loves fighting, good head of hair". I don't care about what people say about us and what they see from us in this situation.

isis-killer-beheading-video-story-top Meghan Markle's Half-Sister Travels to London, Only to Be Shunned
Oct 02, 2018 - 03:00
Mr Edwards said: "I think Harry would have told her the downside of being in the royal family and there is a lot of downsides". With people making a mockery out of their family, she wanted to put a stop to it.

isis-killer-beheading-video-story-top Lawrence Culp, new GE CEO, faces tall task reviving aging conglomerate
Oct 02, 2018 - 02:08
Flannery replaced Welch successor Immelt , himself pushed out earlier than expected last summer after nearly 16 years at the top. It will take a charge of about $23 billion to write down what's called "goodwill", the intangible value of the power division.

isis-killer-beheading-video-story-top How to watch Rockies vs. Dodgers, NL West Tiebreaker
Oct 02, 2018 - 01:46
The Central winner would then host the WC winner in one half of the NLDS, with the West winner hosting Atlanta in the other half. We know that the Los Angeles Dodgers will be playing in the Major League Baseball postseason for the sixth straight year.

isis-killer-beheading-video-story-top Yale turns on Kavanaugh
Oct 02, 2018 - 01:16
A number of you have written to me to express concerns about Judge Kavanaugh's teaching in the Winter Term 2019. Gerken echoed the ABA, which on Thursday urged the committee to delay a confirmation vote on Kavanaugh.

isis-killer-beheading-video-story-top Emery swerves questions over Ramsey's future at Arsenal
Oct 01, 2018 - 04:32
Javi Gracia's team opened at a ferocious tempo and were the better team for long periods, especially in the second half. We need to continue being calm, and giving them calm".

isis-killer-beheading-video-story-top Mark Judge To Cooperate With FBI On Brett Kavanaugh Sexual Assault Investigation
Oct 01, 2018 - 04:14
Flake suggested the probe be limited to the current allegations against Kavanaugh. The Kavanaugh senate confirmation hearing has divided women across the country.

isis-killer-beheading-video-story-top Hurricane Rosa heading for Baja California weakens in Pacific
Oct 01, 2018 - 02:44
On the forecast track, the center of Rosa will approach the central and northern Baja California peninsula on Monday. Heavy rainfall and flooding will become likely early next week to mid- week over the desert to the southwest.

isis-killer-beheading-video-story-top Fortnite Season 6 Has Arrived, Includes Pets, Shadow Stones, and New Skins
Oct 01, 2018 - 02:32
There's Bonesy, a dog; Scales, a teeny tiny dragon; and Camo, a cute chameleon who happens to be my personal favorite. There are three pets in all being introduced in season 6 , and they're all exclusive to the Battle Pass .

isis-killer-beheading-video-story-top Trump Says Secret to Fake Peace With North Korea Was Real Love
Oct 01, 2018 - 00:56
Trump said at the Saturday night rally in West Virginia: "He wrote me handsome letters and they're great letters. Donald Trump has said that he and Kim Jong-un "fell in love" after writing "beautiful letters" to each other.

isis-killer-beheading-video-story-top Messi warns Barcelona not to depend on him
Oct 01, 2018 - 00:47
Lionel Messi and Gerard Pique struggled to come to terms with Barcelona's defeat. 'We can't be conceding goals in every game . In Seville, Real were met by a rampant home team who took the lead in the 17th minute through Portuguese striker Andre Silva.

isis-killer-beheading-video-story-top India to Address the United Nations General Assembly Today
Sep 30, 2018 - 22:39
Moreover, FM Qureshi said that he will be meeting US Secretary of State Mike Pompeo on October 2 to discuss bilateral matters. Swaraj and Pakistani Foreign Minister Shah Mahmood Qureshi were supposed to meet on the sidelines of the U.N.